Colocalization of myostatin and decorin in bovine skeletal muscle
نویسندگان
چکیده
منابع مشابه
Relationships between transforming growth factor-beta1, myostatin, and decorin: implications for skeletal muscle fibrosis.
Recent studies have shown that myostatin, first identified as a negative regulator of skeletal muscle growth, may also be involved in the formation of fibrosis within skeletal muscle. In this study, we further explored the potential role of myostatin in skeletal muscle fibrosis, as well as its interaction with both transforming growth factor-beta1 and decorin. We discovered that myostatin stimu...
متن کاملRelationships between Tgf-β1, Myostatin, and Decorin: Implications for Skeletal Muscle Fibrosis*
Recent studies have shown that myostatin, first identified as a negative regulator of skeletal muscle growth, may also be involved in the formation of fibrosis within skeletal muscle. In this study, we further explored the potential role of myostatin in skeletal muscle fibrosis, as well as its interaction with both transforming growth factor-beta1 and decorin. We discovered that myostatin stimu...
متن کاملMyostatin in the Pathophysiology of Skeletal Muscle
Myostatin is an endogenous, negative regulator of muscle growth determining both muscle fiber number and size. The myostatin pathway is conserved across diverse species ranging from zebrafish to humans. Experimental models of muscle growth and regeneration have implicated myostatin as an important mediator of catabolic pathways in muscle cells. Inhibition of this pathway has emerged as a promis...
متن کاملFHL1 activates myostatin signalling in skeletal muscle and promotes atrophy
Myostatin is a TGFβ family ligand that reduces muscle mass. In cancer cells, TGFβ signalling is increased by the protein FHL1. Consequently, FHL1 may promote signalling by myostatin. We therefore tested the ability of FHL1 to regulate myostatin function. FHL1 increased the myostatin activity on a SMAD reporter and increased myostatin dependent myotube wasting. In mice, independent expression of...
متن کاملTransforming growth factor- and myostatin signaling in skeletal muscle
Kollias HD, McDermott JC. Transforming growth factorand myostatin signaling in skeletal muscle. J Appl Physiol 104: 579 –587, 2008; doi:10.1152/japplphysiol.01091.2007.—The superfamily of transforming growth factor(TGF) cytokines has been shown to have profound effects on cellular proliferation, differentiation, and growth. Recently, there have been major advances in our understanding of the si...
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ژورنال
عنوان ژورنال: Archives Animal Breeding
سال: 2011
ISSN: 2363-9822
DOI: 10.5194/aab-54-147-2011